IndraLab

Statements

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"Here we show that IU1, a small-molecule inhibitor of the proteasome-associated deubiquitinating enzyme USP14, impairs viral replication."
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"At the same time, USP14 has been suggested to negatively regulate immune responses and promote viral replication [ 23 ]."
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"Lowering USP14 levels can inhibit viral replication, whereas agonizing USP14 restores viral replication (Ming et al., 2022)."
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"Consistently, replenishment of USP14 in USP14 null cells restored viral replication."
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"Ablation of USP14 also influenced PRV replication, whereas replenishment of USP14 in USP14 null cells restored viral replication."
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