IndraLab

Statements

USP1 increases the amount of TBK1. 3 / 3
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"Among the USP members, USP1 functions as a viral infection-induced physiological enhancer of TBK1 expression when bound to USP1 the K48-linked polyubiquitination of TBK1, resulting in enhanced TLR3/4 and RIG-I-induced IRF3 activation and IFNb secretion (74) ."
34707613
reach
"Among the USP members, USP1 functions as a viral infection-induced physiological enhancer of TBK1 expression when bound to USP1 the K48-linked polyubiquitination of TBK1, resulting in enhanced TLR3/4 and RIG-I-induced IRF3 activation and IFNβ secretion (74)."
34707613
reach
"Consistently, UAF1 and USP1 knockdown also significantly decreased TBK1 protein level in both SeV- and LPS stimulated macrophages (XREF_FIG)."
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