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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

UCHL1 inhibits MDM2. 2 / 2

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"They also observed an increase in polyubiquitination and degradation of mdm2 in response to UCH-L1 over-expression, suggesting UCH-L1 suppresses mdm2 to stabilize p53 levels [XREF_BIBR]."

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"Thus , in breast cancer models , UCHL1 can induce the levels of p53 and reduce mdm2 protein levels ."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...