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IGF2BP2 activates USP13. 2 / 2

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"Mechanically, USP13’s m A modification is catalyzed by METTL3, and IGF2BP2 promotes USP13 mRNA translation by identifying m A residues on USP13 transcripts, ultimately triggering autophagy [169]."

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"On the contrary, IGF2BP2 elevates the stability of a deubiquitinase ubiquitin specific peptidase 13 (USP13) to prolong the half-life of autophagy-related protein 5 (ATG5), inducing pro-survival autophagy and drug resistance in gastrointestinal stromal tumors 60."

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IGF2BP2 activates USP13. 2 / 2

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