IndraLab

Statements

BAP1 inhibits Ubiquitin. 2 / 2
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"Whereas BAP1 encodes for an ubiquitin C-terminal hydrolase (deubiquitinase, DUB) and is therefore able to reverse the ubiquitin linkages formed by E3 ubiquitin ligases, NF2 encodes for a negative regulator of the E3 ubiquitin ligase CRL4 DCAF1."
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"After transfection of Flag-FOXO3a, HA-BAP1 and various ubiquitin mutants (K48, K63, K48R and K63R) into 293T cells, it was observed that BAP1 predominantly reduced the ubiquitin modification of the FOXO3a protein at the K48 position, thereby verified the experimental findings regarding the half-life of FOXO3a."
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