IndraLab

Statements

STAMBP is ubiquitinated. 5 / 5
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"The difference is that STAMBP does not affect the protein abundance of NLRP3, but STAMBP deficiency enhances the K63-linked ubiquitin chain of NLRP3, and the non-degraded STAMBP ubiquitination process favors NLRP3 inflammasome activation ( xref )."
34966378
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"We have shown that RNF11 binds to AMSH and, in the presence of the E3 ligase Smurf2, promotes the ubiquitination and degradation of the AMSH protein [40]."
16925951
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"It acts as an adaptor for the Smurf2-mediated ubiquitylation of AMSH, a deubiquitylating enzyme acting in the endocytic pathway, leading to its degradation [47] ."
19070615
sparser
"RNF11 may mediate AMSH ubiquitination through the formation of the Smurf2/RNF11 complex, leading to its degradation by the 26S proteasome, negatively regulating TGF-β signaling ( xref )."
39185411
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"MS analysis of EGFR-AMSH ubiquitination demonstrated that the fraction of K63 linkages was substantially reduced, whereas relative amounts of monoubiquitin and K48 linkages increased, compared with that of wild-type EGFR."
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