IndraLab

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TP53BP1 activates USP28. 3 / 3
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"We show that USP28 dimerization is stimulated by 53BP1—the major binding partner of USP28 and a key mediator protein in cellular response to DNA damage and replicative stress (41,86–89)."
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"Depletion of 53BP1 in p19 Nras cells diminished USP28 dimerization (Figure 5C; Supplementary Figure S5E), mimicking the effect of etoposide."
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"Given that p53 activity is quenched via MDM2 dependent p53 ubiquitination, it is tempting to speculate that a 53BP1 dependent targeting of USP28 into p53 protein complexes might counteract such events."
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