IndraLab

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CDC25 activates KCNMA1. 4 / 4
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"Tissue specific rescue experiments demonstrated that ctn-1 mediates SLO-1 function in neurons independent of the dystrophin complex (XREF_FIG)."
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"Another intriguing conclusion from our data is that loss of CTN-1 does not completely abolish SLO-1 function."
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"Yet, the loss of ctn-1 function suppresses the sluggish movement of slo-1 (gf) and mimics slo-1 mutant phenotypes, including hyperactive foraging and jerky movement [XREF_BIBR]."
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"In conclusion, we have identified ctn-1, a gene encoding the C. elegans homolog of alpha-catulin, and demonstrated that CTN-1 mediates SLO-1 localization in muscles and neurons by dystrophin complex dependent and -independent mechanisms, respectively."
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