IndraLab

Statements

Saquinavir inhibits KCNH2. 5 / 5
| 5
reach
"Anson et al. [XREF_BIBR] demonstrated that RTV, LPV, NFV, and saquinavir substantially suppress HERG currents expressed in HEK293 cells and the corresponding endogenous current, I Kr, in mouse neonatal myocytes."
20736017
reach
"In silico test to measure whether Saquinavir and its analogs may (not) block the HERG K + ion channels of the heart suggest S2 to be a better molecule with minimum HERG inhibition value of 0.12 followed by S1 (0.13) and Saquinavir drug (0.14)."
24966525
reach
"In vitro, lopinavir, nelfinavir, ritonavir, and saquinavir caused dose dependent hERG channel blockade."
33345848
reach
"Thus, a potentially complex contribution and interplay between direct hERG blocking and hERG trafficking by saquinavir may potentially contribute to the day-to-day variability seen in mean maximum incrementQTcF dense."
25742730
reach
"Drug induced QT prolongation is usually caused by block of human ether-a-go-go-related gene (HERG) potassium channels, and we showed that lopinavir, nelfinavir, ritonavir, and saquinavir caused dose dependent block of HERG channels heterologously expressed in HEK293 cells in vitro."
15721475