IndraLab

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KCNH2 activates NS1643. 2 / 2
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"In single and double substitution-mutant forms of the channel, NS1643-dependent channel activation and the molecular modeling details have led to a hypothesis that mutation-induced conformational chan[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Interestingly, application of the selective hERG1 blocker E4031 in combination with NS1643 rescued the effect of NS1643 alone (XREF_FIG; G0/G1 = 52% +/-4% S = 28% +/-6% G2/M = 5% +/-2%) confirming the specificity of hERG1 channel in determining its agonist dependent inhibition of cell proliferation."
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