IndraLab

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OGT activates BAP1. 5 / 5
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"Taken together, our data suggest that OGT-mediated O -GlcNAcylation, which likely targets BAP1, prompts BAP1 to repress RAR-induced gene activation.Given the positive role of OGT in maintaining the se[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Using in vivo and in vitro approaches, we examined the OGT-mediated O -GlcNAcylation of BAP1."
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"Reversely, OGT mediates the O-GlcNAcylation of BAP1 by interacting with BAP1 C-terminal region [20]."
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"In addition, positive crosstalk between BAP1 and OGT may exist because BAP1 stabilizes OGT as a deubiquitinase [12] and OGT potentiates BAP1 as an RAR repressor via O -GlcNAcylation.Although our data [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"To determine whether BAP1 O -GlcNAcylation is directly driven by OGT, we performed glycosylation assays in vitro using purified proteins."
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