IndraLab

Statements

USP37 binds ERK. 9 / 9
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"As shown in xref , the N-terminal region of USP37 (1–330 aa) was critical for the interaction between USP37 and ERK1/2."
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"To investigate the biological function of the USP37-ERK1/2 axis in lung cancer cells in vivo, shRNAs were stably transfected into NCI-A549 cells, which were subcutaneously implanted into nude mice and monitored for tumor growth."
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"A coimmunoprecipitation assay was then performed to confirm the interaction between endogenous USP37 and ERK1/2."
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"The interaction between USP37 and ERK1/2 was further confirmed using a reciprocal coimmunoprecipitation assay (Fig. 3 D)."
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"In addition, the binding between USP37 and ERK1/2 was further confirmed using bacterially expressed GST-USP37 proteins (Fig. 3 E)."
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"As shown in Fig. 3 F, the N-terminal region of USP37 (1–330 aa) was critical for the interaction between USP37 and ERK1/2."
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"USP37 interacts with ERK1/2."
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"A coimmunoprecipitation assay was then performed to confirm the interaction between endogenous USP37 and ERK1/2."
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"The interaction between USP37 and ERK1/2 was further confirmed using a reciprocal coimmunoprecipitation assay ( xref )."
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