IndraLab

Statements

USP11 activates SOX11. 5 / 5
| 5
reach
"This Sox11 down-regulation was rescued by re-expression of wild-type Usp11, but not Usp11 R241Q (XREF_FIG)."
33579706
reach
"Whereas expression of wild-type Usp11 increased Sox11 abundance, this mutant did not up-regulate Sox11 (XREF_FIG)."
33579706
reach
"In summary, our study identifies the functions of Usp11 mediated Sox11 stabilization in cortical development, provides an explanation for the association of Usp11 mutation with neurological disorder, and highlights the importance of deubiquitination triggered protein stabilization in the developmental process."
33579706
reach
"It is intriguing that Usp11 targets Sox11, but not its paralog Sox4, in the developing cortex."
33579706
reach
"Last, using a cycloheximide-chase assay, we found that Usp11 knockdown decreased the stability of Sox11 (XREF_FIG)."
33579706