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USP32 activates NFASC. 4 / 4
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"In addition, IHC analysis of DLD1 and HCT116 xenograft tumours confirmed that USP32 could positively regulate the NF‐κB signalling pathway (Figure 7C)."
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"In conclusion, our study has found that USP32 promotes CRC development by activating the NF‐κB signalling pathway, and the USP32 –NF‐κB axis may act as a potential target for CRC therapy."
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"In the present study, we discovered that NF‐κB signalling is activated by USP32 overexpression and that the inhibition of the USP32–NF‐κB axis could reverse the proliferation, colony formation, anti‐apoptosis and migration abilities of CRC cells.To further verify USP32's oncogenic roles, we also performed in vivo studies."
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"Second, USP32 primarily performs biological functions by mediating the de‐ubiquitination process, and the mechanism of how USP32 activates NF‐κB expression remains unexplored.5 Conclusions."
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