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Mutated HCN4 inhibits Heart Rate. 1 / 1
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"Due to this property, HCN channels have been thought to play a critical role in the positive chronotropic effect of beta-adrenergic stimulation (DiFrancesco, 2010) However, genetic ablation of cAMP sensitivity of HCN4 as well as transgenic overexpression of mutant HCN4 (HCN4-573X-Tg) that produces dominant negative suppression of cAMP sensitivity in heteromeric HCN channels did not inhibit beta-adrenergic acceleration of the HR (Harzheim etal."