IndraLab

Statements

KL activates KCNQ1. 4 / 6
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"KCNQ1 and KCNE1 expressing oocytes were treated with human recombinant Klotho protein (30 ng/mL) for 24 h. Moreover, oocytes which express both KCNQ1 and KCNE1 and Klotho were treated with 10 muM DSA L (D-saccharic acid-1,4-lactone), a beta-glucuronidase inhibitor."
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"KCNQ1 and KCNE1 channel activity and KCNQ1 and KCNE1 protein abundance were upregulated by coexpression of Klotho."
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"Upregulation of KCNQ1 and KCNE1 K+ channels by Klotho."
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"In conclusion, Klotho upregulates KCNQ1 and KCNE1 channel activity by " mainly " enhancing channel protein abundance in the plasma cell membrane, an effect at least partially mediated through the beta-glucuronidase activity of Klotho protein."
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