IndraLab

Statements

KL activates KCNQ1. 4 / 6
| 4
reach
"KCNQ1 and KCNE1 channel activity and KCNQ1 and KCNE1 protein abundance were upregulated by coexpression of Klotho."
24457979
reach
"KCNQ1 and KCNE1 expressing oocytes were treated with human recombinant Klotho protein (30 ng/mL) for 24 h. Moreover, oocytes which express both KCNQ1 and KCNE1 and Klotho were treated with 10 muM DSA L (D-saccharic acid-1,4-lactone), a beta-glucuronidase inhibitor."
24457979
reach
"Upregulation of KCNQ1 and KCNE1 K+ channels by Klotho."
24457979
reach
"In conclusion, Klotho upregulates KCNQ1 and KCNE1 channel activity by " mainly " enhancing channel protein abundance in the plasma cell membrane, an effect at least partially mediated through the beta-glucuronidase activity of Klotho protein."
24457979