IndraLab

Statements

UCHL5 deubiquitinates SMAD3. 4 / 5
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"In the present study, we demonstrate that UCHL5 de-ubiquitinates and stabilizes Smad2 and Smad3, thereby promoting TGFbeta-1 signaling."
27604640
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"UCH5/UCH37 deubiquitinates both smad2 and smad3 to promote TGFβ-1 induced lung fibrosis [70]."
32650621
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"Here, we demonstrate that UCHL5 de-ubiquitinates and stabilizes Smad2 and Smad3, thereby promoting TGFbeta-1 signaling and contributes to the pathogenesis of pulmonary fibrosis."
27604640
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"Also, OTUB1 regulates only phosphorylated Smad2 and Smad3 under TGFbeta-1 treatment XREF_BIBR, while UCHL5 de-ubiquitinates Smad2 and Smad3 regardless of TGFbeta-1 treatment."
27604640