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E2F1 binds BAP1. 13 / 13
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"Chromatin immunoprecipitation (ChIP) assays revealed that BAP1 binds to E2F1 gene promoters, and knockdown of BAP1 leads to increased H2AK119ub1 enrichment, which may lead to transcriptional inactivat[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25582751
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"It showed that BAP1 was greatly reduced at the promoters ( p < 0.05; Fig. 4 E), but no effects on E2F1 occupancy were observed ( Fig. 4 C), suggesting that HCF-1 served as a scaffold for BAP1 to bind [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"BAP1 binds to E2F1-responsive gene promoters through HCF-1 and upregulates their expression, and BAP1 KO inhibits the growth of uveal melanoma cells ."
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No evidence text available
33547197
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No evidence text available
35140242
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"HCF-1 knockdown abolished BAP1 binding to E2F1-responsive promoters, whereas BAP1 knockdown had no effects on HCF-1 enrichment, indicating that HCF-1 possibly acts as a scaffold to recruit BAP1 to spe[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Pan et al. have indicated that BAP1 may interact with promoters regulated by E2F1 and affect the cell cycle progression genes controlled by E2F. xref "
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"Our findings suggest that SUFU’s role in CRC is determined not only by its interaction with key molecules like BAP1 and E2F1 but also through Hh-independent mechanisms."
41484776
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"Chromatin immunoprecipitation (ChIP) assays revealed that BAP1 binds to E2F1 gene promoters, and knockdown of BAP1 leads to increased H2AK119ub1 enrichment, which may lead to transcriptional inactivat[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25582751
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"Hence, ChIP-reChIP was performed and the result revealed that BAP1 binds with E2F1 as well as HCF-1 on the E2F1 responsive gene promoter ( Fig. 4 G and H), suggesting that these proteins co-occupy the[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"E2F1 recruitment of BAP1 to E2F-responsive promoters may also proceed via more direct mechanisms that remain uncharacterized.Studies have confirmed the interaction between BAP1 and HCF-1 ( Misaghi et [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25582751
reach
"HCF-1 knockdown abolished BAP1 binding to E2F1-responsive promoters, whereas BAP1 knockdown had no effects on HCF-1 enrichment, indicating that HCF-1 possibly acts as a scaffold to recruit BAP1 to spe[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25582751
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"This establishes SUFU as a non-canonical driver of CRC growth with mechanistic dependence on the BAP1-E2F1 axis rather than Hh pathway activation."
41484776