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USP7 decreases the amount of CDKN1A. 2 / 2

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"Knockdown of USP7 or USP47 increased the protein levels of p53 and the mRNA levels of CDKN1A, a p53 target gene encoding p21 protein, without affecting p53 gene expression (Figs."

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"HCT116 USP7 -/- cells grow extremely slowly because USP7 knockout leads to constitutively high level of p53 and p21."

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IndraLab

Statements

USP7 decreases the amount of CDKN1A. 2 / 2

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