IndraLab

Statements

IGF1 activates KCNN1. 2 / 2
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"Notably, IGF-1, one of the most important physiological regulator of skeletal muscle regeneration (Pedersen and Febbraio, xref ), activates both SK isoforms, SK1 and SK2, and via specific transactivation of S1P 2 , exerts its myogenic action (Bernacchioni et al., xref )."
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"These data demonstrate that enhanced biosynthesis of S1P, due to SK1 and SK2 activation induced by IGF-1, is responsible for the engagement of S1P 1 and S1P 3 and is negatively implicated in the mitogenic effect of the growth factor."
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