IndraLab

Statements

OTUB1 inhibits TRAF3. 4 / 4
| 3 1
reach
"TRAF3 and TRAF6 are both deactivated by the DUbs otubain 1 (OTUB1) and OTUB2, which remove K63 linked polyubiquitin chains."
26712804
reach
"TRAF3 are inhibited by DUBA, OTUB1 and UCHL1 that specilally remove TRAF3 K63‐linked ubiquitination."
28744851
reach
"To modulate type-I IFN response FAT10 can operate at two levels: targeting TRIM21 for proteasomal degradation, thereby inhibiting TRIM21-mediated activation of MAVS and IRF3 (Yang et al, 2009; Xue et al, 2018), and activating OTUB1 which inhibits TRAF3 activation (Bialas et al, 2019)."
38977311
sparser
"TRAF3 are inhibited by DUBA, OTUB1 and UCHL1 that specilally remove TRAF3 K63‐linked ubiquitination."
28744851