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USP25 activates IFIH1. 1 / 1

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"Interestingly, we found that overexpression of USP21 WT but not C221A mutant inhibited IFN-beta, NF-kappaB, and ISRE reporter activities in HEK293T cells in response to transfected poly (I : C), which was known to be mediated by MDA5 (unpublished data), suggesting that USP21 might also target MDA5."

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USP25 activates IFIH1. 1 / 1

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