IndraLab

Statements

USP20 deubiquitinates SLC7A11. 5 / 5
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"Ectopic expression of USP20‐WT, but not USP20 , markedly reduced the ubiquitylation of SLC7A11."
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"In vivo deubiquitylation assays showed that USP20 reduced SLC7A11 polyubiquitination in a time‐ and dose‐dependent manner."
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"To Further analysis indicated that K30 and K37 are the key sites on SLC7A11 deubiquitinated by USP20."
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"Conversely, the deubiquitinating enzymes OTUB1 and ubiquitin specific peptidase 20 (USP20) mediate the deubiquitination of SLC7A11, thereby stabilizing SLC7A11 levels in cancer cells [6,122]."
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"Ubiquitination assay indicated that K30 and K37 were the key sites on SLC7A11 deubiquitinated by USP20 (Figure 5G)."
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