IndraLab

Statements

Probucol activates KCNH2. 6 / 6
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"Therefore, these results demonstrate that matrine and oxymatrine could rescue probucol induced hERG deficiency, which may lead to potentially effective clinical therapeutic drugs for treating cardiotoxicity in the future."
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"To identify the damage of hERG current induced by probucol depended on the decrease of protein level but not channel functions, patch-clamp recordings were used to detect the long-term effect of probucol on hERG-channel kinetics."
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"We also demonstrated that matrine and oxymatrine were able to upregulate Sp1 expression which may be one of the possible mechanisms that by which matrine and oxymatrine rescued probucol induced hERG channel deficiency."
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"On the contrary, carbachol could enhance the phosphorylation level of Nedd4-2 as an alternative to SGK1, and thus rescue the ubiquitin mediated degradation of hERG channels caused by probucol."
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"Likewise, CCh (25 and 50 muM) reversed the downregulation of I hERG induced by 100 muM probucol (XREF_FIG)."
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"This seems to be a result of enhanced degradation of plasma membrane hERG protein induced by probucol treatment."
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