IndraLab

Statements

CYLD activates TLR. 3 / 3
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"CYLD also inhibits TRAF2 and NEMO (NF-κB essential modulator, a regulatory subunit of IKK), and blocks NF-κB signaling downstream to TLR activation [176-178] ."
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"Some others are deubiquitinases (DUBs), such as A20 (also known as TNFAIP3), CYLD (cylindromatosis D), and DUBA (deubiquitinating enzyme A), which negatively modulate TLR signaling by removing the K63[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Finally, the DUB CYLD might modulate TLR signalling, as demonstrated in CYLD deficient macrophages, which were found to be hyper-responsive to LPS stimulation."
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