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BAP1 bound to ASXL1 activates IRF8. 1 / 1

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"This hyperactive mutant ASXL1 and BAP1 complex induces upregulation of posterior HOXA genes and IRF8 through inhibition of H2AK119ub, impairing multilineage differentiation of haematopoietic progenitors (except for that toward monocytes), and accelerates RUNX1-ETO-induced leukaemogenesis."

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IndraLab

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BAP1 bound to ASXL1 activates IRF8. 1 / 1

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