IndraLab

Statements

UBE2D1 activates OTUB1. 3 / 4
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"Taken together, our results suggest that OTUB1 should be stimulated by uncharged UBCH5 in cells, and that variations in the ratio of E2 to E2 ~ Ub could be involved in regulating OTUB1 isopeptidase activity."
23955022
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"Together, these E2 enzymes are in 2.7-fold molar excess over OTUB1 and have a combined concentration of nearly 10 times the EC 50 for UBCH5 stimulation of OTUB1 DUB activity (XREF_FIG)."
23955022
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"These findings suggest that UBCH5A augmented OTUB1’s noncanonical activity through a mechanism that involves S-glutathionylation of OTUB1 at either position C23 or C204."
37703360