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2-[1-ethylsulfonyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1-pyrazolyl]-3-azetidinyl]acetonitrile inhibits STAT1. 2 / 2

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"Although baricitinib completely inhibited the IFN stimulated activation of STAT1, the effects on DCs were partial; baricitinib has almost no inhibitory effect on Tyk2, allowing persistent activity of the Tyk2 pathway for IRF7."

30002661

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reach

"The data in Figure 5 suggests that baricitinib, which negatively regulates STAT1 and pSTAT1, overrides the elevated innate immunity associated with SAMHD1 loss."

35085552

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IndraLab

Statements

2-[1-ethylsulfonyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1-pyrazolyl]-3-azetidinyl]acetonitrile inhibits STAT1. 2 / 2

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