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USP13 increases the amount of ATG5. 2 / 2
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reach
"Also, our results indicated that upregulation of METTL3 in USP13-knockdown 143B cells rescued the downregulated ATG5 mRNA, while silencing of METTL3 in USP13-overexpressing HOS cells decreased the upregulated ATG5 mRNA level (Fig. 6l)."
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signor
"Here, we identified USP13 as an essential deubiquitinase that stabilizes ATG5 in a process that depends on the PAK1 serine/threonine-protein kinase and which enhances autophagy and promotes IM resistance in GIST cells."
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