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USP8 activates ITCH. 2 / 2

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"One study showed that USP8 acts downstream of PTEN to enhance the ability of the E3 ligase Itch to reduce cFLIP stability and increase tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) sensitivity in human glioblastoma multiforme cells [97]."

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"ITCH and AIP4 activity was activated by the deubiquitinases USP8 and USP9X, as demonstrated by RNA interference."

27203743

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USP8 activates ITCH. 2 / 2

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