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Cholesterol inhibits TBK1. 2 / 2
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"Intracellular cholesterol depletion potentiates IFN signaling by increasing the responsiveness of the STING/TBK1 axis regulating the activation of IFN regulatory factor 3, a key transcription factor d[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Addition of free cholesterol to SREBP2-knockout cells significantly decreased pTBK1, while blocking IFNAR had no effect on pTBK1 levels, reinforcing the idea that cholesterol directly influences STING mediated activation of TBK1."
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