IndraLab

Statements

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"Therefore, it will be important to investigate the mechanism underlying the tumor-promoting effect of BAP1 inactivation in each cell type.In summary, this study demonstrated that Bap1 loss promotes tumorigenesis only in the tissues in which Bap1 is not engaged in pro-survival gene expression, providing an explanation for the tissue specificity of the BAP1 cancer predisposition syndrome."
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"If the loss of either NF2 or BAP1 mediates oncogenesis via the perturbation of Hippo signalling, the failure to take into account the additional Hippo kinase module inactivating events present in PM may have confounded previous efforts to stratify patients according to mutation status."
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"It remains to be established as to how the oxidation-mediated functional loss and misfolding of BAP1 may lead to oncogenesis in a similar mechanism."
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"A subsequent study reported that BAP1 modulated gene expression in a cell-type specific manner, and loss of BAP1 promoted tumorigenesis in cells that did not engage an RNF2-dependent apoptotic program ."
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"BAP1 can promote ferroptosis and suppress tumor tumorigenesis [39]."
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"Loss of one BAP1 allele either inherited or acquired during life has been associated with environmental stress-induced carcinogenesis, like UV light for uveal melanoma and asbestos for mesothelioma."
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"In mice, BAP1 loss in the germ line is embryonic lethal (10), and BAP1 loss in the developing kidney causes differentiation failure and tumorigenesis (11)."
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"Paradoxically, despite the fact that BAP1 loss promotes tumorigenesis, BAP1 inactivation causes cell death in many cell types."
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"p53 and BRCA1 Associated Protein 1 (BAP1) inhibit carcinogenesis in part by antagonizing SLC7A11 and induce ferroptosis (Zhang Y. et al., 2019)."
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