IndraLab

Statements

USP1 activates Death. 3 / 3
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"Genetic silencing and pharmacological suppression of USP1 blocked beta-cell death in several experimental models of diabetes in vitro and ex vivo without compromising insulin content and secretion and without impairing beta-cell maturation/identity genes in human islets."
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"In the present study, we found through shRNA screening that USP1 downregulation induced growth arrest and death of CRC cells."
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"Taken together, high USP1 levels, driven by EWS::FLI1, stabilize Survivin protein and promotes EWS cell survival by inhibiting the activation of death effector caspases-3/7 in the presence of endogenous replication stress and DNA damage (Fig. 7H, left)."
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