IndraLab

Statements


USP46 inhibits HYCC1. 5 / 5
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"In summary, our results confirm that USP46 suppresses HCC proliferation and growth in vivo and in vitro ."

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"In functional investigations, USP46 knockdown increased cell proliferation and invasiveness in vitro and in vivo whereas overexpression of USP46 decreased HCC cell proliferation and metastasis."

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"Indeed, USP46 inhibition significantly increased YAP1, as well as the proliferation and metastasis of HCC cells."

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"However, tumor cells were resuspended in serum-free medium when we conducted invasion and migration assays, which showed that USP46 inhibits both the proliferation and invasion of HCC cells."

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"Furthermore, our results demonstrated that USP46 suppresses HCC proliferation and metastasis by inhibiting the MST1/YAP1 axis."