IndraLab

Statements

TRAF6 activates CYLD. 4 / 5
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"In BCL10-deficient Jurkat cells, ectopic expression of TRAF6 induced CYLD cleavage by MALT1-WT but not by the dimerization defective MALT1-R551E mutant [ 17 ] ( Fig. 3 A)."
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"40 RANKL stimulated osteoclastogenesis potently induces the expression of CYLD, and the accumulated CYLD targets TRAF6 by interacting with the adaptor protein, p62."
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"When co-expressed with MALT1 and CYLD in WT Jurkat T-cells, TRAF6 induced CYLD cleavage ( Fig. 2 A)."
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"Addition of the PRKC inhibitor AEB071, to blunt potential basal CBM formation, did not impact TRAF6-mediated CYLD cleavage ( Fig. 2 A)."
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