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DNAJA1 inhibits KCNH2. 2 / 2
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"Hsp40 co-chaperones also regulate Kv11.1 maturation: Overexpression of DNAJA1, and to a lesser extent the homologous DNAJA2 and DNAJA4 isoforms, impairs Kv11.1 trafficking."
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"Our observations are thus similar to those described by Walker and colleagues, who reported that DnaJA1, DnaJA2 and DnaJA4 reduced hERG channel maturation, whereas over-expression of Hsc70 alone had no effect on maturation events XREF_BIBR."
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