IndraLab
Statements
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"We next used an alternative approach to confirm that the loss of CYLD in T cells causes the constitutive activation of IKKbeta."
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"However, because Cyld deficiency did not cause the activation of ERK, the target of CYLD might be an intermediate signaling factor specifically mediating the activation of JNK and IKKbeta."
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"Augmented CYLD activity suppressed IKKbeta which stabilized IkappaBalpha and retained NF-kappaB dimers in their inactive states in the cytosol."
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"Surprisingly, the loss of CYLD did not result in the basal activation of IKKbeta or Tak1 in macrophages."
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"These results establish a pivotal role for CYLD in controlling Tak1 function and explain how CYLD negatively regulates IKKbeta and JNK."
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"YM155 activated CYLD activity which led to suppressed IKKbeta activity and stabilization of inhibitory IkappaBalpha."