IndraLab

Statements

Salicylate inhibits CASP1. 4 / 4
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"Our study added SAL as another agent that targets NLRP3 inflammasome in protection on endothelial damage, which is supported by a recent report that SAL suppresses caspase-1 activation and IL-1beta release in LPS induced HUVECs [XREF_BIBR]."
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"Sal B was reported to inhibit pyroptosis by downregulating pyroptosis related proteins GSDMD, caspase-1, and IL-1beta."
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"Furthermore, SAL also decreased the activation of caspase-1 and inhibited the release of IL-1beta induced by lipopolysaccharide (LPS) and adenosine triphosphate (ATP) in human umbilical vein endothelial cell (HUVECs)."
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"Another study found that Sal B could inhibit caspase-1 and GSDMD-mediated pyroptosis and thereby alleviate I/R injury in mice, by activating Nrf2 and NLRP3 signaling pathway [XREF_BIBR]."
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