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Pyruvic acid inhibits RELA. 9 / 9
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"It is important to investigate how much the NF-kappaB pathway is involved in the different models of inflammation and whether or not ethyl pyruvate inhibits the functions of NF-kappaB in each model.Pr[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Next, we examined whether ethyl pyruvate inhibited the binding of RelA (1-220) or p50 to the [32 P]-labeled NF-kappaB probe."
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"Studies in vitro suggested that ethyl pyruvate inhibited p65 by covalently modifying cysteine residues necessary for its DNA binding [XREF_BIBR]."
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"Furthermore, immunostaining of A549 cells revealed that ethyl pyruvate inhibited the nuclear association of RelA after TNFalpha treatment."
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"It was also reported that ethyl pyruvate inhibited the nuclear association of RelA in human umbilical vein endothelial cells (Johansson et al., 2008; Mizutani et al., 2010)."
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"Moreover, the levels of phospho-NF-KappaB p65 and phospho-IKappaBalpha were obviously increased in AVMC mice (P < 0.01); however, the presence of ethyl pyruvate reduced phospho-NF-KappaB p65 and phospho-IKappaBalpha (P < 0.05; Fig."
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"In the present study, we confirmed that ethyl pyruvate inhibited the nuclear association of RelA with immunostaining methods."
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"Ethyl pyruvate was suggested to inhibit NF-kappaB and DNA-binding activity by alkylating RelA at cysteine 38 (Han et al., 2005)."
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"However, ethyl pyruvate directly inhibited binding of the p65 subunit of NF-kappaB to DNA while having no effect on the p50 subunit."
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