IndraLab

Statements


IL17A activates TNFAIP3. 2 / 3
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eidos
"A20 ( Tnfaip3 ) , a deubiquitinase associated with susceptibility to autoimmune syndromes including psoriasis , is upregulated by IL-17A through NF-kappaB ."

reach
"IL-17 increased the abundance of TNFAIP3 mRNA and the subsequent production of A20 protein, which inhibited IL-17-mediated activation of TRAF6, NF-kappaB, and MAPKs, as well as downstream gene expression."