IndraLab

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ADAM17 binds NOTCH1. 11 / 13
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"To further promote Notch activation, TRP120 binds the promoter regions of Notch1 and ADAM17 to promote transcription during infection ( xref )."
40028182
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"This study reveals a novel effector-dependent mechanism, which involves interaction with the ADAM17 and Notch1 and activation of canonical Notch signaling pathway in monocytes, a primary target of E. chaffeensis , to modulate ERK1/2 and p38 MAPK pathways and regulate TLR2/4 expression ( xref )."
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"Thus, we generated a spatial neighbourhood network ( xref ), where in health we observed dominant interactions between suprabasal and basal epithelial layers ( MMP9-LRP1; ADAM17-NOTCH1 ) ( xref , xref )."
36648332
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"As shown in xref , iNOS overexpression or Pet-cGMP treatment led to serine/threonine phosphorylation of TACE (detected using an antiphosphothreonine antibody) and an interaction between phosphorylated TACE and Notch1 in LCSCs."
30297396
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"The activation of Notch signaling, particularly through the DLL4-NOTCH1 and ADAM17-NOTCH1 pathways, was markedly observed transitioning from high-senescence endothelial cells to astrocytes (Fig.  xref F-G), indicating the pivotal role of the Notch pathway in the progression of MDD."
40033248
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"This interaction between Notch1 O -glycosylation and cleavage by ADAM17 is involved in the mechanism of heterotaxy."
33218200
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"In the healthy mucosa, we detected increased interactions between basal and suprabasal epithelial cells governed by ADAM17 and NOTCH1 ."
36648332
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"Double immunofluorescence showed strong signals for Notch1 and TACE immunostaining, which were predominantly distributed in CD68 positive macrophages compared with control tissues.In the present study[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25744398
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"These interactions, including the DLL4-NOTCH1 and ADAM17-NOTCH1 receptor pairs, suggest that senescent endothelial cells communicate with astrocytes through pathways critical for immune regulation."
40033248
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"In our communication analyses, we detected high probability of interactions between ADAM17-NOTCH1."
36648332
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"DSThighM macrophages exhibited a close association with endothelial cells in terms of IL6-IL6ST, MFNG-NOTCH1, OSM-IL6ST, ADAM17-NOTCH1, VEGF1-FLT1, VEGF2-FLT1, and PDGFC-FLT1 ligand-receptor linkages."
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