IndraLab

Statements

CACNA1A activates Kir6. 5 / 5
| 5
sparser
"Glutamate substitution at position 168 results in somewhat unusual effects on conduction, including intrinsic inward rectification (in the absence of intracellular blockers), but these do not resemble the unique voltage-dependent activation of Kir6.2[L157E]."
20208975
sparser
"Several observations confirm that voltage-dependent activation of Kir6.2[L157E] is due to channel gating, rather than an alternative mechanism such as relief of block, a voltage-dependent change in conductance, or activation of an alternative channel type in the patch."
20208975
sparser
"Such a mechanism may also account for the voltage-dependent activation of Kir6.2[L157E]."
20208975
sparser
"The voltage-dependent activation of Kir6.2[L157E] likely arises from a state preference for one orientation of permeating ions over another (specifically, whether the cavity site is occupied is vacant)."
20208975
sparser
"While not as dramatic as the voltage-dependent activation of Kir6.2[L157E], these features can be quite obvious and are exaggerated in modest inhibitory concentrations of ATP."
20208975