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P5091 activates TP53. 5 / 5
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"P5091 downregulated MDM2 and upregulated p53 in WI‐38 SnCs but not in WI‐38 non‐SnCs (Figure 1c)."
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"In addition to PTEN, p53 is upregulated by P5091, but its cytotoxic activity is not dependent on p53 ."
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"(A) Surviving fractions of HCT116 p53-/- cells, compared to the p53 wild type, treated with olaparib, P5091 or the combination of the two drugs at the indicated doses for 72 h are shown (the plotted v[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"P5091 treatment effectively induces apoptosis in both TP53 mutated MEC-1 and TP53-wild-type EHEB cell lines and, remarkably, is highly effective in del17p CLL primary CD19 + lymphocytes, with an apoptotic induction ' potency ' like the one observed in TP53-wild type CLL samples."
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"Notably, melatonin induced a marked reduction in proliferation of p53 wild-type NSCLC cells (Fig. 6F) while the combination of P5091 and melatonin elicited strong growth inhibition of p53-deficient NSCLC cells (Fig. 6G)."
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