IndraLab

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Daidzein inhibits STAT1. 13 / 14
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"Flavonoids like genistein, kaempferol, quercetin, and daidzein inhibited STAT-1 and NF-kappa B activations in anti-inflammatory effects [XREF_BIBR]."
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"Genistein, kaempferol, quercetin, and daidzein also inhibited the activation of the signal transducer and activator of transcription 1 (STAT-1), another important transcription factor for iNOS."
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"In addition to these four polyphenols, genistein, kaempferol and daidzein have been reported to inhibit the activation of STAT-1 and NF-κB pathways [ 162 ]."
30550953
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"The mechanisms by which genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 activation are not known, but may be associated with inhibition of phosphorylation of STAT-1 or its up-stream kinase JAK2 [XREF_BIBR]."
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"Daidzein also inhibits STAT-1 and NF-kappaB activations in an activated macrophage [XREF_BIBR]."
28831294
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"Anti-Inflammatory Effects of Flavonoids : Genistein, Kaempferol, Quercetin, and Daidzein Inhibit STAT-1 and NF-kappaB Activations, Whereas Flavone, Isorhamnetin, Naringenin, and Pelargonidin Inhibit only NF-kappaB Activation along with Their Inhibitory Effect on iNOS Expression and NO Production in Activated Macrophages."
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"Similarly, in macrophage, daidzein inhibited the activation of STAT-1 and NF-kB proteins, thereby decreased the expression of iNOS and the production of NO [XREF_BIBR]."
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"In addition, genistein, kaempferol, quercetin, and daidzein also inhibited STAT-1 activation."
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"[24] Hamalainen M, Nieminen R, Vuorela P, Heinonen M, Moilanen E. Anti-inflammatory effects of flavonoids : genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappaB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages."
23841752
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"Daidzein also suppresses inflammation in activated macrophages upon LPS exposure by inhibiting the signal transducer and activator of transcription 1 (STAT-1) and NF-κB activations [22, 23]."
35974408
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"These observation was consistent with the anti-inflammatory effects of some flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF- κ B activation, whereas flavone, isorhamne[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19071231
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"Daidzein, genistein, kaempferol, and quercetin also inhibited the STAT-1 pathway [54]."
35566252
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"Daidzein and genistein also inhibited activations of STAT-1 and NF-kappaB, which are important transcription factors for iNOS [XREF_BIBR, XREF_BIBR]."
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