IndraLab

Statements

SNAI1 decreases the amount of CYLD. 9 / 11
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"Down-regulation of CYLD expression by Snail promotes tumor progression in malignant melanoma."
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"Down-regulation of CYLD expression by Snail promotes tumor progression in malignant melanoma."
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"CYLD expression is downregulated by the transcriptional repressor Snail in both basal cell carcinoma and melanoma."
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"Reduced CYLD expression in basal cell carcinoma was mediated by GLI1 dependent activation of the transcriptional repressor Snail."
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"In malignant melanoma, the expression of CYLD is downregulated by elevated expression of the transcription factor SNAIL1, which results in increased proliferative and migratory potential of melanoma cells (5,6)."
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"Moreover, Snail was found to negatively regulate the transcription levels of CYLD, which promotes tumor progression in malignant melanoma [54] ."
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"However, CYLD mRNA transcription is directly inhibited by Snail [XREF_BIBR] and the Notch target Hes1 [XREF_BIBR], both of which are up-regulated and activated under hypoxic conditions [XREF_BIBR, XREF_BIBR]."
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"Snail also promotes proliferation in a melanoma model by repressing expression of CYLD, a tumor suppressor gene that functions as a deubiquitination enzyme."
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"Snail can inhibit CYLD expression in melanoma [XREF_BIBR]."
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