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Tetracycline inhibits CASP1. 9 / 9
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"Tetracycline dose-dependently reduced caspase-1 activation, indicated by less cleavage of the p45 caspase-1 precursor into its p20 subunit while expression of NLRP3 and ASC, which is upstream of caspase-1, was not affected (Fig. 2A, B) ."
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"Minocycline, a tetracycline antibiotic with high CNS penetration when taken orally, inhibits caspase-1 and caspase-3 enzymes and decreases activity of inducible nitric oxide synthase [53]."
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"In summary, current study suggests that tetracycline inhibits caspase-1 activation in response to silica and ameliorates silica-induced pulmonary inflammation including IL-1ß production, thereby reducing lung injury and fibrotic lung remodeling.Tetracycline reduced caspase-1-dependent production of IL-1β in response to silica in vitro and in vivo."
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"Tetracycline inhibited hyperglycemia induced caspase-1 activity in vitro but not in vivo."
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"Consistent with this, our group recently showed that tetracycline had neither an effect on NF-ƙB dependent gene expression nor on ASC-specking, but rather selectively inhibits activation of caspase-1 in LPS and nigericin activated macrophages [20] ."
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"These results indicate that tetracycline selectively blocks silicainduced IL-1ß production and pyroptosis of BMDM.Since tetracycline decreased both silica-induced IL-1ß production and pyroptosis, we conducted immunoblot analysis to examine whether tetracycline inhibits caspase-1 activation in BMDM in response to silica."
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"Isatin sulfonamides have been described as potent and selective non peptidic caspase-3 and -7 inhibitors [58], but no development has as yet been reported.The second generation tetracycline antibiotic[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Tetracycline selectively blocks IL-1β production and pyroptotic cell death via inhibition of caspase-1 in macrophages exposed to silica particles."
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"To bring these findings back to the bedside, they reexamined the subtype of patients with ARDS that were identified earlier and were able to confirm that tetracycline would limit caspase 1 activity of pulmonary leukocytes.The combination of precision medicine and translation from bed to bench and back is novel to ARDS research and is the major strength of the study."
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