IndraLab

Statements

OTUD5 inhibits Colitis. 3 / 3
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"DUBA inhibited the development of severe DSS colitis through downregulation of type I IFN responses, as knockdown of DUBA expression by administration of DUBA-specific siRNA cancelled the therapeutic effects of MDP injection via upregulation of type I IFN responses."
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"In addition, DUBA deficiency in macrophages rendered mice hypersensitive to DSS-induced colitis and eliminated the protective effect of MDP treatment in colitis."
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"Furthermore, administration of DUBA antisense oligonucleotides (ASOs) attenuates the development of trinitrobenzene sulfonic acid (TNBS) colitis via downregulation of TNF-α expression."
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