IndraLab

Statements


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"USP22 is also found to indirectly promote the expression of MDR-related genes through upregulation of AKT and subsequently activation of the PI3K pathway in HCC [69]."

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"Moreover, USP22 knockdown also decreases MDR related genes expression by inhibiting Akt phosphorylation, and USP22 knockdown mediated Smad4 up-regulation is crucial for Akt suppression."

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"USP22 knockdown decreased MDR related genes expression through up-regulation of Smad4 and suppression of Akt."