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KCNMA1 activates TLR4. 7 / 7
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"Since SLO activates TLR4 in murine bone marrow derived macrophages XREF_BIBR, the molecular mechanisms involved in SLO dependent CysLTs production were dissected using specific inhibitors targeting the TLR4 cell signaling and CysLTs pathway."
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"We show that SLO activates TLR4 of mononuclear cells as suggested by the inhibition of CysLTs production in the presence of CLI095, as was also reported previously xref ."
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"Moreover, SLO activates toll like receptor 4 (TLR4) XREF_BIBR, whose signalling pattern regulates the activation of cytosolic phospholipase A2 (cPLA 2) in LPS activated murine macrophages XREF_BIBR."
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"This redundancy is exemplified by the activation of macrophages via TLR4 signalling from nonstructural bacterial elements, such as GAS cytolysin streptolysin O (SLO), and the inability of singular TLR1, TLR2, TLR4, or TLR9 deficiencies to prevent stimulation of DC cytokine production XREF_BIBR, XREF_BIBR."
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"In addition to its cytolytic activity, the ability of SLO to activate TLR4 signaling could also be involved in apoptosis induction, as demonstrated in macrophages for other cholesterol dependent cytolysins [XREF_BIBR - XREF_BIBR]."
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"Since SLO activates TLR4 in murine bone marrow–derived macrophages xref , the molecular mechanisms involved in SLO-dependent CysLTs production were dissected using specific inhibitors targeting the TLR4 cell signaling and CysLTs pathway."
26860261
reach
"We show that SLO activates TLR4 of mononuclear cells as suggested by the inhibition of CysLTs production in the presence of CLI095, as was also reported previously XREF_BIBR."
26860261