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OTUD3 leads to the ubiquitination of PTEN. 2 / 2

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"Furthermore, several DUBs, including HAUSP/USP7, USP10, USP11, USP13, OTUD3, and Ataxin-3 have been shown to reverse the ubiquitination of PTEN, a key antagonist in the PI3K growth-promoting pathway, implicating its function in cancer-specific contexts [15]."

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"Several studies have demonstrated that OTUD3 interacts with PTEN and induces its deubiquitination, increasing PTEN protein stability and inhibiting carcinogenic PI3K/AKT signaling (89)."

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IndraLab

Statements

OTUD3 leads to the ubiquitination of PTEN. 2 / 2

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